AFAIK you can still install any random APK but the process will require enabling developer mode and one time 24 hour wait period. But the problem is many stupid Apps check that developer mode is on and refuse to work.
An FDroid desktop client that adb installs APKs would actually be lovely. I pretty much exclusively use FDroid, but I gotta say I unfortunately find all their frontends to be rather buggy and with very little user feedback when things break (repo updates are hard to observe, downloads hang, updates mysteriously fail)
Droidify sometimes does a weird thing when installing apps:
1. Ensure Droidify is not running.
2. Launch it.
3. Tell it to install or update to an app.
4. Receive an Android system prompt to approve the install/update.
5. Approve it.
6. Tell Droidify to install or update another app.
7. Reveive a system prompt to approve the action of step #3 again.
8. Approve it.
9. Receive system prompt to approve step #6.
10. Repeat #6 through #9 for more apps.
Workaround: Do steps #1 through #5.
Foxy Droid doesn't have this problem, but won't auto-download updates for you.